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Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA).Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Management of pruritus: Oral: 25 mg 3-4 times/day Intravenous, intra-arterial, and subcutaneous administration are Adult (usual) Allergy: 25 mg orally at bedtime or 12.5 mg orally before meals and at bedtime. Please review the latest applicable package insert for additional information and possible updates.Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.Patients rated symptoms of pruritus, number and maximum size of wheals twice daily.Please see package insert for additional information and possible updates.Sustained-release: 8 or 12 mg po every 8 to 12 hours. Supplied: Extended Release Cap: 6 mg, 8 mg, 12 mg Liquid/syrup: 2 mg/5 ml Tablet: 2 mg, 4 mg.

[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.Adults and children 12 years of age and older: take 1 tablet every 12 hours, not more than 2 tablets in 24 hours unless directed by a doctor.Mechanism of Action Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects.Start with lower doses and increase as needed and tolerated. Measure Karbinal ER with an accurate milliliter measuring device.A household teaspoon is not an accurate measuring device and could lead to overdosage.Desloratadine inhibited histamine release from human mast cells in vitro.

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