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methods rely on characteristic faunal and geological patterns to bracket the period when the fossil existed.At the onset of the 20th century, most scientists had accepted the great antiquity of the earth, the theory of evolution and that humanity had evolved from an ape ancestor, but by 1908 the fossil evidence of early man was scarce.Adaptation is a continuous response to the environment by changeable species.This environment has a living (other animals) and non-living component (e.g. Widgets A unique adaptation usually precedes the entry into a new niche .Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles.

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Living orders of placental mammals , be it bats, humanity, whales or camels, have as their common ancestor a small insectivore creature that went through a major phase of adaptive radiation during the Early Cenozoic Era .

[3] Adaptation is genetically based and so leads to phenotypic changes that accumulate over time; [4] Speciation (species formation) evolves through reproductive isolation and (genetic) divergence of populations; [5] Genetic changes through natural selection lead to new species and eventually new taxa .

The evolution of a species is linked to the environment.

Most drugs after crystallization may have to be comminuted and this physical transformation is required to various extents, often to enhance processability or solubility especially for drugs with limited aqueous solubility.

The mechanisms by which milling enhances drug dissolution and solubility include alterations in the size, specific surface area and shape of the drug particles as well as milling-induced amorphization and/or structural disordering of the drug crystal (mechanochemical activation).

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